Chondroblastic osteosarcoma of the proximal left tibia in the setting of cystic fibrosis related diabetes mellitus. Clinical case

Cystic fibrosis related diabetes (CFRD) is a rare pathology that combines genetically determined systemicity with damage to the exocrine glands, which leads early manifestations of disease, clear exacerbation and chronicity process, possible complications in bone remodeling occurrence malignant tumors. Purpose - acquaint practitioners peculiarities manifestations, diagnosis course chondroblastic osteosarcoma child CFRD. Features clinical differential are described given proximal part left tibia against background CFRD child. The main diagnostic value history, picture, laboratory, instrumental, immunohistochemical microscopic research methods was highlighted, particular, biopsy this tumor. Microscopic examination tissue revealed alternating areas atypical cartilaginous corresponding structure chondrosarcoma 1-2 cm, solid proliferates fibroblast-like cells fibroblastic containing elements osteogenesis. Periosteally randomly oriented fragments at place cortical plate, as well impressions lower metaphysis thigh upper tibia, near knee joint. showed existing CD99-positive tumor (DAKO, clone 12E7). Some were positive for SATB2 (Cell Marque, EP281); negative S-100 SOX-10. histological picture immunophenotype correspond osteosarcoma. Osteosarcoma genetic, metabolic aplastic features developing setting comorbid significantly complicates requires certain changes treatment tactics (correction prophylactic basic therapy, toxic disorders, including those caused by chemotherapy). carried out accordance principles Helsinki Declaration. informed consent patient obtained conducting studies. No conflict interests declared authors.